Feature selection for proximity estimation in COVID-19 contact tracing apps based on Bluetooth Low Energy (BLE).

During the COVID-19 pandemic, contact tracing apps based on the Bluetooth Low Energy (BLE) technology found in smartphones have been deployed by multiple countries despite BLE's debatable performance for determining close contacts among users. Current solutions estimate proximity based on a single feature: the mean attenuation of the BLE signal. In this context, a new generation of these apps which better exploits data from the BLE signal and other sensors available on phones can be fostered. Collected data can be used to extract multiple features that feed machine learning models which can potentially improve the accuracy of today's solutions. In this work, we consider the use of machine learning models to evaluate different feature sets that can be extracted from the received BLE signal, and assess the performance gain as more features are introduced in these models. Since indoor conditions have a strong impact in assessing the risk of being exposed to the SARS-CoV-2, we analyze the environment (indoor or outdoor) role in these models, aiming at understanding the need for apps that could increase proximity accuracy if aware of its environment. Results show that a better accuracy can be obtained in outdoor locations with respect to indoor ones, and that indoor proximity estimation can benefit more from the introduction of more features with respect to the outdoor estimation case. Accuracy can be increased about 10% when multiple features are considered if the device is aware of its environment, reaching a performance of up to 83% in indoor spaces and up to 91% in outdoor ones. These results encourage future contact tracing apps to integrate this awareness not only to better assess the associated risk of a given environment but also to improve the proximity accuracy for detecting close contacts.

¿Superávit de neurocirujanos en Argentina? Análisis estadístico actual y de los próximos años / Neurosurgeon surplus in Argentina? Current statistical analysis and the coming years

La Federación Nacional de Neurocirugía (FNNC) fue fundada en la ciudad de Rosario el 23 de agosto de 2019, con el objetivo de crear una organización que nu-clee a todas las sociedades y asociaciones de neurociru-gía de nuestro país, con un perfil netamente gremial. La FNNC reconoce a la Asociación Argentina de Neuroci-rugía (AANC) como la organización que rige la activi-dad académica-profesional de la neurocirugía en todo el territorio de la República Argentina.Uno de los propósitos principales es lograr condiciones laborales dignas y correctamente remuneradas para to-dos los neurocirujanos que residan en suelo argentino. Pensamos que una de las herramientas necesarias para conseguir dicho propósito es lograr un equilibrio entre el número de neurocirujanos en actividad, el número de plazas de residentes, y el número de habitantes en Ar-gentina.Actualmente no existen datos concretos para realizar un diagnóstico de situación. Es por ello que la FNNC, apoyada y avalada por la AANC, tomó la iniciativa de realizar un análisis descriptivo de la situación actual y su proyección en los próximos años en relación con el nú-mero de neurocirujanos en Argentina.El objetivo del presente trabajo es presentar de forma sintética y clara los aspectos más relevantes de dicho es-tudio.

Preliminary study between Y chromosome haplogroups and chagasic cardiomyopathy manifestations in patients with Chagas disease.

INTRODUCTION: Among patients with Chagas disease, men have a higher risk of worse pathological symptoms than women. We aimed to explore the role of the Y chromosome in men diagnosed with Chagas disease and assess the relationship between their ancestry and disease status. METHODS: In this comparative study, we analyzed 150 men with unrelated non-chagasic disease (nCD) and 150 men with unrelated chagasic disease (CD). We assessed the serological diagnosis of Chagas disease, biochemical parameters, thoracic X-rays, electrocardiogram, and transthoracic echocardiography and determined the haplogroup by analyzing a set of 17 microsatellites from the Y chromosome. We examined the associations between common Y chromosome haplogroups and the clinical parameters of risk by logistic regression. RESULTS: For all patients, the most common haplogroups were R1b (43%), G2a (9%), and E1b1b (9%). The R1b and G2a haplogroup was more frequent in men with nCD and CD, respectively. As expected, we observed a high proportion of symptomatic patients in the CD group independent of the haplogroups. Men from both groups classified as having the R1b haplogroup showed less clinical evidence of disease. Multivariate analysis showed that CD patients without R1b were about five times more likely to have a cardio-thorax index >0.5% (OR [odds ratio] = 5.1, 95% CI [confidence interval] = 3.31-8.17). Men without the R1b haplogroup were 2.5 times more likely to show EcoCG alterations (OR = 2.50, 95% CI = 0.16-3.94). CONCLUSIONS: Our results provided evidence that the R1b haplogroup may have a potential protective cardiovascular effect for its carriers.

Preliminary study between Y chromosome haplogroups and chagasic cardiomyopathy manifestations in patients with Chagas disease

Abstract INTRODUCTION: Among patients with Chagas disease, men have a higher risk of worse pathological symptoms than women. We aimed to explore the role of the Y chromosome in men diagnosed with Chagas disease and assess the relationship between their ancestry and disease status. METHODS In this comparative study, we analyzed 150 men with unrelated non-chagasic disease (nCD) and 150 men with unrelated chagasic disease (CD). We assessed the serological diagnosis of Chagas disease, biochemical parameters, thoracic X-rays, electrocardiogram, and transthoracic echocardiography and determined the haplogroup by analyzing a set of 17 microsatellites from the Y chromosome. We examined the associations between common Y chromosome haplogroups and the clinical parameters of risk by logistic regression. RESULTS For all patients, the most common haplogroups were R1b (43%), G2a (9%), and E1b1b (9%). The R1b and G2a haplogroup was more frequent in men with nCD and CD, respectively. As expected, we observed a high proportion of symptomatic patients in the CD group independent of the haplogroups. Men from both groups classified as having the R1b haplogroup showed less clinical evidence of disease. Multivariate analysis showed that CD patients without R1b were about five times more likely to have a cardio-thorax index >0.5% (OR [odds ratio] = 5.1, 95% CI [confidence interval] = 3.31-8.17). Men without the R1b haplogroup were 2.5 times more likely to show EcoCG alterations (OR = 2.50, 95% CI = 0.16-3.94). CONCLUSIONS: Our results provided evidence that the R1b haplogroup may have a potential protective cardiovascular effect for its carriers.

[Glycerol kinase deficiency in adult patient: hypertriglyceridemia resistance to diet and pharmacological treatment]. / Déficit de glicerol kinasa en el adulto: hipertrigliceridemia resistente a tratamiento dietético y farmacológico.

CASE REPORT: we present an 85-year-old patient with polydipsia, polyuria and severe hypertriglyceridemia of 27 years of evolution, without pancreatitis, resistant to dietary and pharmacological treatments. He was diagnosed of hyperglycerolemia due to glycerol kinase deficiency (GKD) based on: transparent non-lipemic serum, with glycerol increase in plasma and urine, without glycerol 3 phosphate increase, and a deletion, not previously described, in the glycerol kinase gene. DISCUSSION: a correct dietary treatment with frequent meals and rich in complex carbohydrates, without medication, improved the symptomatology.

Caso clínico: presentamos un paciente varón de 85 años con polidipsia, poliuria e hipertrigliceridemia severa de 27 años de evolución, sin pancreatitis, persistente y resistente a tratamientos dietético y farmacológico. Se diagnosticó de hiperglicerolemia por déficit de glicerol kinasa (GKD) en base a: suero transparente no lipémico, aumento de glicerol en plasma y orina, sin aumento de glicerol 3 fosfato y deleción, no descrita previamente, en el gen de la glicerol kinasa.Discusión: un tratamiento dietético correcto con comidas frecuentes y rico en carbohidratos complejos, sin medicación, mejoró la sintomatología.

Déficit de glicerol kinasa en el adulto: hipertrigliceridemia resistente a tratamiento dietético y farmacológico / Glycerol kinase deficiency in adult patient: hypertriglyceridemia resistance to diet and pharmacological treatment

Caso clínico: presentamos un paciente varón de 85 años con polidipsia, poliuria e hipertrigliceridemia severa de 27 años de evolución, sin pancreatitis, persistente y resistente a tratamientos dietético y farmacológico. Se diagnosticó de hiperglicerolemia por déficit de glicerol kinasa (GKD) en base a: suero transparente no lipémico, aumento de glicerol en plasma y orina, sin aumento de glicerol 3 fosfato y deleción, no descrita previamente, en el gen de la glicerol kinasa. Discusión: un tratamiento dietético correcto con comidas frecuentes y rico en carbohidratos complejos, sin medicación, mejoró la sintomatología

Case report: we present an 85-year-old patient with polydipsia, polyuria and severe hypertriglyceridemia of 27 years of evolution, without pancreatitis, resistant to dietary and pharmacological treatments. He was diagnosed of hyperglycerolemia due to glycerol kinase defi ciency (GKD) based on: transparent non-lipemic serum, with glycerol increase in plasma and urine, without glycerol 3 phosphate increase, and a deletion, not previously described, in the glycerol kinase gene. Discussion: a correct dietary treatment with frequent meals and rich in complex carbohydrates, without medication, improved the symptomatology

Sialoadenitis por radioyodo. Análisis de factores que influyen en la respuesta al tratamiento médico / Sialadenitis after radioiodine therapy. Analysis of factors that influence the response to medical treatment

OBJETIVOS: Estudiar la incidencia de sialoadenitis (SD) por 131I en pacientes con cáncer diferenciado de tiroides (CDT), analizar los factores clínicos y otros vinculados a radioterapia metabólica que puedan predecir la falta de respuesta al tratamiento médico convencional (TMC) y determinar la eficacia de la instilación intraductal del Stenon (ITS) en pacientes con fracaso al TMC. MATERIAL Y MÉTODOS: Cincuenta y dos pacientes con CDT, 45 mujeres (86,5%) y 7 hombres (13,5%), con edad media 44,21 ± 13,3 años, que postiroidectomía total recibieron dosis ablativa de 131I. Excluimos individuos con enfermedades/medicación causantes de xerostomía. Realizamos gammagrafía de glándulas salivales con 99Tc (10mCi). RESULTADOS: Presentaron SD 18 pacientes (34,62%) tratados con antibióticos, antiespasmódicos y corticoides vía oral durante 15 días. Se les dividió en 2 grupos: respuesta al tratamiento médico n = 12 (67%), edad 44,3 ± 14,4 años, 2 hombres (17%), 10 mujeres (83%), dosis acumulativa 225 ± 167 mCi; y sin respuesta al tratamiento médico, n = 6 (33%), a los que se instiló corticoides en conducto de Stenon; edad 50 ± 13,8 años, 2 hombres (33%), 4 mujeres (67%), dosis acumulativa 138,3 ± 61,7 mCi. Demostramos lesiones en la gammagrafía de glándulas parótidas y submaxilares. CONCLUSIÓN: La incidencia de sialoadenitis por 131I fue similar a la descripta por otros autores. La edad, la dosis media acumulada de 131I y la afectación de glándulas parótidas o submaxilares no condicionaron diferente respuesta al TMC, solo relacionada con el sexo masculino. La persistencia de síntomas durante más de 15 días hace recomendable la ITS de corticoides, método eficaz y seguro para preservar dichas glándulas ante otras opciones como la exéresis quirúrgica

OBJECTIVES: To assess the incidence of 131I-induced sialadenitis (SD) in patients with differentiated thyroid cancer (DTC), to analyze clinical and other factors related to metabolic radiotherapy that may predict the lack of response to conventional medical therapy (CMT), and to determine the effectiveness of intraductal steroid instillation in patients failing CMT. MATERIAL AND METHODS: Fifty-two patients with DTC, 45 females (86.5%) and 7 males (13.5%) with a mean age of 44.21 ± 13.3 years (r = 17-74) who received ablation therapy with 131I after total thyroidectomy. Patients with diseases and/or medication causing xerostomia were excluded. Patients underwent salivary gland scintigraphy with 99Tc (10mCi). RESULTS: Eighteen patients (34.62%) had SD and received antibiotics, antispasmodics, and oral steroids for 15 days. They were divided into two groups: responders to medical therapy (n = 12, age 44.3 ± 14.4 years, 2 men [17%], 10 women [83%], cumulative dose 225 ± 167.1 mCi) and non-responders to medical treatment, who underwent steroid instillation into the Stensen's duct (n = 6 [33%], 2 men [33%], 4 women [67%], age 50 ± 13.8 years, cumulative dose 138.3 ± 61.7 mCi). Scintigraphy showed damage to the parotid and submaxillary glands. CONCLUSION: Incidence of 131I-induced sialadenitis was similar to that reported by other authors. Age, mean cumulative dose of 131I, and involvement of parotid and submaxillary glands did not condition response to CMT; however, male sex was a conditioning factor. Symptom persistence for more than 15 days makes instillation into the Stensen's duct advisable. This is an effective and safe method to avoid surgical excision of salivary glands

Sialadenitis after radioiodine therapy. Analysis of factors that influence the response to medical treatment.

OBJECTIVES: To assess the incidence of 131I-induced sialadenitis (SD) in patients with differentiated thyroid cancer (DTC), to analyze clinical and other factors related to metabolic radiotherapy that may predict the lack of response to conventional medical therapy (CMT), and to determine the effectiveness of intraductal steroid instillation in patients failing CMT. MATERIAL AND METHODS: Fifty-two patients with DTC, 45 females (86.5%) and 7 males (13.5%) with a mean age of 44.21±13.3 years (r=17-74) who received ablation therapy with 131I after total thyroidectomy. Patients with diseases and/or medication causing xerostomia were excluded. Patients underwent salivary gland scintigraphy with 99Tc (10mCi). RESULTS: Eighteen patients (34.62%) had SD and received antibiotics, antispasmodics, and oral steroids for 15 days. They were divided into two groups: responders to medical therapy (n=12, age 44.3±14.4 years, 2 men [17%], 10 women [83%], cumulative dose 225±167.1 mCi) and non-responders to medical treatment, who underwent steroid instillation into the Stensen's duct (n=6 [33%], 2 men [33%], 4 women [67%], age 50±13.8 years, cumulative dose 138.3±61.7 mCi). Scintigraphy showed damage to the parotid and submaxillary glands. CONCLUSION: Incidence of 131I-induced sialadenitis was similar to that reported by other authors. Age, mean cumulative dose of 131I, and involvement of parotid and submaxillary glands did not condition response to CMT; however, male sex was a conditioning factor. Symptom persistence for more than 15 days makes instillation into the Stensen's duct advisable. This is an effective and safe method to avoid surgical excision of salivary glands.

Expression of VEGF-A, HIF-1 A, CD34 and Ki67 in clear cell renal cell carcinomas and their relationship with conventional prognostic markers.

Clear cell renal carcinoma is the most frequent type of renal carcinoma. Recently, attention has been focused in the expression of angiogenic factors by these tumors, which would justify in part their capacity to grow, invade and disseminate, stating a worse evolution of those patients with an unfavorable angiogenic profile. 83 samples of nephrectomy with a diagnosis of clear cell renal cell carcinoma were studied. Clinical and pathological data were collected. Tumors were studied to assess immunohistochemical expression of the following markers: VEGF-A, HIF-1α, CD34 and Ki67. Results indicated a direct linear relationship between expressions of these four markers. Besides, the expression of HIF-1α was directly related to Furhman grade, invasion of the renal vein and tumor stage. Likewise, tumor proliferation index, assessed with Ki67, was directly related to the presence of necrosis, capsular invasion and advanced tumor stage. Regarding the expression of CD34, vascular density was inversely related to tumor necrosis and overall survival. These findings are controversial compared with the available literature. Then, a research scenery would be open, where the importance of generating prospective and more standardized studies are highlighted to determine the role of these angiogenic factors in tumor evolution and prognostic evaluation of these tumors.

El carcinoma renal de células claras es la variante más frecuente de carcinoma renal. En los últimos años, la atención se ha enfocado en la expresión de factores angiogénicos por estos tumores, lo que justificaría en parte su capacidad de crecer, invadir y diseminarse, determinando una peor evolución de aquellos pacientes con un perfil angiogénico desfavorable. Se estudiaron 83 piezas de nefrectomía con diagnóstico de carcinoma renal de células claras. Se recolectaron datos clínicos y patológicos. Los tumores fueron estudiados para evaluar la expresión inmunohistoquímica de los siguientes marcadores: VEGF-A, HIF-1α, CD34 y Ki67. Los resultados indicaron una relación lineal directa entre la expresión de estos cuatro marcadores. Además, la expresión de HIF-1α se encontraba directamente relacionada con el grado de Furhman, la invasión de la vena renal y el estadio tumoral. Asimismo, el índice de proliferación tumoral, evaluado con Ki67, se hallaba directamente relacionado con la presencia de necrosis, la invasión capsular y el estadio tumoral avanzado. Con respecto a la expresión de CD34, mientras mayor es la densidad vascular, menor es la necrosis tumoral y menor la sobrevida global. Los hallazgos resultan controvertidos en comparación con la literatura disponible. Se abriría, entonces, un escenario de investigación donde se destaca la importancia de generar estudios prospectivos y más estandarizados para determinar el rol que cumplen estos factores angiogénicos en la evolución tumoral y la posibilidad de estandarizar resultados que permitan un mejor estudio diagnóstico y pronóstico de estos tumores.

Expression of VEGF-A, HIF-1 A, CD34 and Ki67 in clear cell renal cell carcinomas and their relationship with conventional prognostic markers / Expression of VEGF-A, HIF-1 A, CD34 and Ki67 in clear cell renal cell carcinomas and their relationship with conventional prognostic markers.

Clear cell renal carcinoma is the most frequent type of renal carcinoma. Recently, attention has been focused in the expression of angiogenic factors by these tumors, which would justify in part their capacity to grow, invade and disseminate, stating a worse evolution of those patients with an unfavorable angiogenic profile. 83 samples of nephrectomy with a diagnosis of clear cell renal cell carcinoma were studied. Clinical and pathological data were collected. Tumors were studied to assess immunohistochemical expression of the following markers: VEGF-A, HIF-1α, CD34 and Ki67. Results indicated a direct linear relationship between expressions of these four markers. Besides, the expression of HIF-1α was directly related to Furhman grade, invasion of the renal vein and tumor stage. Likewise, tumor proliferation index, assessed with Ki67, was directly related to the presence of necrosis, capsular invasion and advanced tumor stage. Regarding the expression of CD34, vascular density was inversely related to tumor necrosis and overall survival. These findings are controversial compared with the available literature. Then, a research scenery would be open, where the importance of generating prospective and more standardized studies are highlighted to determine the role of these angiogenic factors in tumor evolution and prognostic evaluation of these tumors.

Expression of VEGF-A, HIF-1 A, CD34 and Ki67 in clear cell renal cell carcinomas and their relationship with conventional prognostic markers. / Expression of VEGF-A, HIF-1 A, CD34 and Ki67 in clear cell renal cell carcinomas and their relationship with conventional prognostic markers.

Clear cell renal carcinoma is the most frequent type of renal carcinoma. Recently, attention has been focused in the expression of angiogenic factors by these tumors, which would justify in part their capacity to grow, invade and disseminate, stating a worse evolution of those patients with an unfavorable angiogenic profile. 83 samples of nephrectomy with a diagnosis of clear cell renal cell carcinoma were studied. Clinical and pathological data were collected. Tumors were studied to assess immunohistochemical expression of the following markers: VEGF-A, HIF-1α, CD34 and Ki67. Results indicated a direct linear relationship between expressions of these four markers. Besides, the expression of HIF-1α was directly related to Furhman grade, invasion of the renal vein and tumor stage. Likewise, tumor proliferation index, assessed with Ki67, was directly related to the presence of necrosis, capsular invasion and advanced tumor stage. Regarding the expression of CD34, vascular density was inversely related to tumor necrosis and overall survival. These findings are controversial compared with the available literature. Then, a research scenery would be open, where the importance of generating prospective and more standardized studies are highlighted to determine the role of these angiogenic factors in tumor evolution and prognostic evaluation of these tumors.

Estado nutricional de adultos mayores beneficiarios de un programa social con componente alimentario implementado en la ciudad de Córdoba. Año 2000 / Nutritional status in older adults beneficiaries of a social programme with food component implemented in the city of Cordoba. Year 2000

El estado nutricional de los adultos mayores es la resultante de sus condiciones de vida y de salud. El aumento demográfico de este segmento de población es un reto a los profesionales de la salud, para lograr conocer cuales son las características de normalidad en esta etapa de la vida. Objetivo general: Conocer el estado nutricional de la población de adultos mayores beneficiarios del programa ASOMA, e identificar desde un enfoque cualitativo, sus patrones alimentarios. Material y métodos:. Estudio descriptivo, correlacional, transversal y de campo. Universo: 10214 ancianos beneficiarios de tres programas alimentarios. Muestreo: aleatorio estratificado. Tamaño de la muestra: 387 ancianos. Respetando la proporcionalidad del universo, Programa ASOMA n=162. Técnicas: Observacionales y medicionales (antropométricas). Ecuaciones: Chumlea para estimar talla a partir de la altura de la rodilla e Indice de Masa Corporal IMC. Conclusiones: El grupo estudiado (n=162) estuvo representado en sus 2/3 partes por el sexo femenino (n=108), perteneciendo en su mayoría a la categoría de viejos-jóvenes (personas de 60- 69 años de edad), con características de pobreza estructural en sus indicadores socioeconómicos: bajo nivel de escolaridad (analfabetismo funcional: 75 por ciento), ingresos temporarios, por debajo de $ 200 mensuales, provenientes en la mitad de los casos de la ayuda familiar. La cuarta parte de los ancianos aún trabaja. Más de la mitad de los ancianos eran propietarios de la vivienda que habitaban, que compartian en el 86 por ciento de los casos con sus familiares. Los alimentos básicos de la dieta eran predominantemente energéticos (pan, azúcar y aceite), y los alimentos de consumo frecuente fueron el arroz y la carne de pollo. Vegetales de los tres grupos, la carne de vaca y frutas del grupo "A" aparecen en sus dietas en menor proporción y frecuencia. El 83,9 por ciento de los ancianos tiene una dieta monótona (consumo semanal de £5 alimentos diferentes), recibidos en el bolsón alimentario del programa ASOMA. La media del IMC fue de 27,4 kg/m2 con un desvío estándar de 5,33, siendo los valores extremos encontrados de 16,20 y de 46,60. El 24,1 por ciento de la población se ubicó en valores de IMC que indican normalidad en el estado nutricional de los ancianos Los valores de IMC según sexo mostraron en hombres un agrupamiento de los datos alrededor de valores normales y colindantes (malnutrición leve por déficit y por exceso). En mujeres, los...

Estado nutricional de adultos mayores beneficiarios de un programa social con componente alimentario implementado en la ciudad de Córdoba. Año 2000 / Nutritional status in older adults beneficiaries of a social programme with food component implemented in the city of Cordoba. Year 2000

El estado nutricional de los adultos mayores es la resultante de sus condiciones de vida y de salud. El aumento demográfico de este segmento de población es un reto a los profesionales de la salud, para lograr conocer cuales son las características de normalidad en esta etapa de la vida. Objetivo general: Conocer el estado nutricional de la población de adultos mayores beneficiarios del programa ASOMA, e identificar desde un enfoque cualitativo, sus patrones alimentarios. Material y métodos:. Estudio descriptivo, correlacional, transversal y de campo. Universo: 10214 ancianos beneficiarios de tres programas alimentarios. Muestreo: aleatorio estratificado. Tamaño de la muestra: 387 ancianos. Respetando la proporcionalidad del universo, Programa ASOMA n=162. Técnicas: Observacionales y medicionales (antropométricas). Ecuaciones: Chumlea para estimar talla a partir de la altura de la rodilla e Indice de Masa Corporal IMC. Conclusiones: El grupo estudiado (n=162) estuvo representado en sus 2/3 partes por el sexo femenino (n=108), perteneciendo en su mayoría a la categoría de viejos-jóvenes (personas de 60- 69 años de edad), con características de pobreza estructural en sus indicadores socioeconómicos: bajo nivel de escolaridad (analfabetismo funcional: 75 por ciento), ingresos temporarios, por debajo de $ 200 mensuales, provenientes en la mitad de los casos de la ayuda familiar. La cuarta parte de los ancianos aún trabaja. Más de la mitad de los ancianos eran propietarios de la vivienda que habitaban, que compartian en el 86 por ciento de los casos con sus familiares. Los alimentos básicos de la dieta eran predominantemente energéticos (pan, azúcar y aceite), y los alimentos de consumo frecuente fueron el arroz y la carne de pollo. Vegetales de los tres grupos, la carne de vaca y frutas del grupo "A" aparecen en sus dietas en menor proporción y frecuencia. El 83,9 por ciento de los ancianos tiene una dieta monótona (consumo semanal de ú5 alimentos diferentes), recibidos en el bolsón alimentario del programa ASOMA. La media del IMC fue de 27,4 kg/m2 con un desvío estándar de 5,33, siendo los valores extremos encontrados de 16,20 y de 46,60. El 24,1 por ciento de la población se ubicó en valores de IMC que indican normalidad en el estado nutricional de los ancianos Los valores de IMC según sexo mostraron en hombres un agrupamiento de los datos alrededor de valores normales y colindantes (malnutrición leve por déficit y por exceso). En mujeres, los... (Au)